The great harlot "sits" on many waters. Later in this chapter, in verse 15, we are told that the waters represent people: "15 And he said to me, "The waters which you saw where the harlot sits, are peoples and multitudes and nations and tongues."
She has universal support around the world. Her influence crosses counties, cultures and people groups.
The Bible describes both sexual and spiritual promiscuity as harlotry. In some cases, even commerce and trade among nations is called playing the harlot:
Lev 20:5-6 (spiritual harlotry)(5) then I Myself will set My face against that man and against his family, and I will cut off from among their people both him and all those who play the harlot after him, by playing the harlot after Molech. (6) 'As for the person who turns to mediums and to spiritists, to play the harlot after them, I will also set My face against that person and will cut him off from among his people.
Isa 1:21 (harlotry as the violent who pervert justice)"How the faithful city has become a harlot, She [who] was full of justice! Righteousness once lodged in her, But now murderers."
Eze 6:9 (spiritual harlotry"Then those of you who escape will remember Me among the nations to which they will be carried captive, how I have been hurt by their adulterous hearts which turned away from Me, and by their eyes which played the harlot after their idols; and they will loathe themselves in their own sight for the evils which they have committed, for all their abominations."
Isaiah 23:16-18 (commercial harlotry)"Take your harp, walk about the city,
O forgotten harlot;
Pluck the strings skillfully, sing many songs,
That you may be remembered.
17 It will come about at the end of seventy years that the Lord will visit Tyre.
Then she will go back to her harlot’s wages
and will play the harlot with all the kingdoms on the face of the earth.
18 Her gain and her harlot’s wages will be set apart to the Lord; . . ."
The great harlot is a new character. There are a number of clues to her identity, but John never reveals her name.
From this description, it is difficult to understand what or who this harlot represents. There are several options:
"34 “Therefore, behold, I am sending you prophets and wise men and scribes; some of them you will kill and crucify, and some of them you will scourge in your synagogues, and persecute from city to city, 35 so that upon you may fall the guilt of all the righteous blood shed on earth, from the blood of righteous Abel to the blood of Zechariah, the son of Berechiah, whom you murdered between the temple and the altar. 36 Truly I say to you, all these things will come upon this generation."
It is likely that this religious system will incorporate other religions and a more "relaxed" acceptance of immoral sexual practices and occult activities.